HRT and quality of sleep
Many women experience disturbed sleep as a menopausal symptom, which can have a significant effect on mood and energy levels and cause distress, and lead to increased risk of heart disease, diabetes and obesity.
Use of Hormone Therapy if you carry the BRCA gene
The effect on breast cancer risk for women who carry the BRCA gene and the use of HRT after removal of ovaries for risk-reducing surgery.
HRT instead of anti-depressants
For some women depression in their 40s can be hormonal as Ursula Hirschkorn - writing in The Telegraph, 30 June 2015 - found out, and since being treated with tailored Hormone Replacement Therapy her quality of life has vastly improved.