Guy’s hospital in conjunction with King’s College London are recruiting women for a study to investigate which form of hormone treatment (if any) is preferable for women with premature ovarian failure (POF).

This study is designed to look at the effects of no treatment/HRT/combined oral contraceptive pill (COCP) on the bones, cardiovascular system, ovarian function, control of symptoms, sexual function, depression score and quality of life over a period of 2 years. 

Those taking part will be able to choose whether to be in the ‘no treatment’ or ‘active treatment’ group.  If they choose to be in the ‘active treatment’ group, they will be allocated to taking HRT or COCP using a method similar to tossing a coin.  They will not be able to choose which they take but will know which it is. 

Those who do take part in the trial will have a comprehensive health assessment relevant to their condition.

Premature Ovarian Failure

Premature ovarian failure is a devastating diagnosis for many young women and often long-term hormone replacement therapy (HRT) is suggested to help with symptoms and try to prevent many of the complications that arise due to an early loss of oestrogen. However, recent trials have suggested concerns for long-term HRT, but these have all been performed in much older women (50-79yrs).

Interested in taking part ?

If you know of women aged below 45 years, who have been diagnosed with premature ovarian failure within the last 3 years and may be interested in taking part in this research study, please ask them to contact the Menopause Research Unit at Guy’s Hospital on:


Tel: 0207 188 3024

(If there is no answer, please leave a name and phone number and they will get back to you.)

There is no obligation to take part and they will be happy to discuss the study further with you and answer any questions that you or your patients have regarding the research.

Ethical approval has been obtained for this study from Guy’s Research Ethics Committee